Furthermore, the metabolic and hormonal profile of our population is not only consistent with ED presence but also reinforces the usefulness of MetS screening for ED and CV disease prevention [9, 25–27]. Comparison measurements are further described in Table 1. (6) Smoking status, (%) Never smoked 55. All these conditions often coexist in the same patient [9, 10], whilst hypogonadism and ED have been demonstrated to increase the risk of MetS [9, 11–15], supporting the idea of a multifactorial/directional endocrinological imbalance that occurs in specific subsets of ED patients.

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Our policy towards the use of cookies All Clarivate Analytics websites use cookies to improve your online experience. 001 Smoker 32. A translator, editor, producer, and inventor are a few examples. Ongoing efforts to expand the numbers of RCTs and further improve the quality of research published by the IJIR will improve clinical practice.

In addition to sexual hormones disturbances, several other endocrinological imbalances might be found in ED patients.

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A retrospective database including all patients with EEC who had surgery at a tertiary referral institution from 1990 to 2020 was created. 8% describing it as moderate/severe, and that ED was most prevalent amongst men over the age of 60 [3]. Collection's Items (Sorted by Submit Date in Descending order): Although hypogonadism was present in 23. Age, TSH, FSH, and estradiol levels presented no significant differences between patients with or without MetS ( , , , , resp.) Levels of FSH, TSH, T3, and T4 were also measured and are described in Table 1.

(10 nmol/L) or calculated FT below 0. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. Is pycnogenol good for your sex life? A randomized, controlled study. 1225 ng/mL (0. )Sexual outcomes were hypothesized to be related to those of urinary ones.

  • Numerous and frequently-updated resource results are available from this WorldCat.
  • Exstrophy-epispadias complex (EEC) is a spectrum of genitourinary malformations that ranges in severity and affects external genitalia and the lower urinary tract.
  • Our results further enlighten this still unclear multidisciplinary and complex subject, raising new investigational opportunities.


Triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were determined by chemiluminescence with a commercially available kit (Abbott Diagnostics Division, Princeton, NJ, USA). 90 μU/mL, respectively. Reliable information about the coronavirus (COVID-19) is available from the World Health Organization (current situation, international travel). 0% from 1995 to 2025 [2]. (2) Former intake 2. Pharmacokinetics of Testosterone Gel for Hypogonadism A once daily application of 2% testosterone gel was shown to dry quickly and was effective in reaching target testosterone concentrations in men with hypogonadism, a new study reports. 4%) and 4 (12.

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Numbers of low risk of bias articles were 1 (3. )This includes Jr. (3) Former intake 63. The relationship between hypogonadism and MetS was also evaluated. 94 μU/mL and T4 levels in the normal range or <0. Publisher country is. 1%) in the early, mid and late periods in Cochrane Collaboration Risk of Bias Tool (P=0. In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism [10, 16].

35 μU/mL, T3 levels >3. One of the most plausible mechanisms by which obesity contributes to T levels decline is the adipose tissue dependent aromatization of T to estradiol [15]. 60 μU/mL and superior to 24. LH levels were considered normal from 1. We hypothesize that, in our group of patients with MetS that did not present estrogenic HPG axis-attenuation effect, obesity is playing an important role in the estradiol levels increase. You always have the option to delete your Tweet location history.

In this study, we describe the hormonal milieu of a Portuguese population with ED, comparing MetS to non-MetS groups and correlating T levels with the number of MetS parameters.

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Other - PDF, Powerpoint, MP4, etc. An alternative etiopathogenic explanation for this phenomenon proposes that fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion [9]. Icd-10 version:2020, 32 Erectile dysfunction following radical cystectomy N52. LetPub, I have decided to work with you more in the future.

The table below outlines in detail the ISO 4 rules and matches to the ISSN maintained list of title word abbreviations (TWA) to derive the abbreviation. All data analyses were performed using STATA software, version 9. Its prevalence in Portuguese male population is 18. (3) Participants with MetS versus participants without MetS. Multivariate regression analysis also demonstrated that the MetS is a determinant independent of lower TT levels independent of the other model variables such as age, alcohol consumption, and smoking habits (beta coefficient: )

Usually gives a brief summary and/or your thoughts about the source. What are the most common erectile dysfunction symptoms? The loss of erectile function can have a profound effect on a man. For example, the publishing company of a book. Even though we did not evaluate the influence of PDE5i on the hormonal axis, we cannot exclude the role these drugs might have in the serum T : Moreover, we analyze the hypothalamic-pituitary-gonadal (HPG) axis in ED patients with and without hypogonadism, aiming to describe and evaluate nonexpected hormonal alterations in this axis and further uncover the relation between these three increasingly prevalent conditions.


It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations. Thus, although the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T. Seventy-nine percent of men and 67% of women reported sexual satisfaction; 63% of men reported normal ejaculation.

Our results yield further insights into this still unclear multidisciplinary and complex subject and raise new research opportunities on alternative factors mediating the relationship between ED, hypogonadism, and MetS.

Furthermore, it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels [33, 34]. For example, Jr. Read the complete collection here We hope you enjoy. March 9, 2020: URL Web address for a page on the internet. Much of the effort involved therefore goes to preserving as much of the native tissue as possible whilst novel and creative methods have been adopted to repair defects and in creation of neophallus.


To restore access and understand how to better interact with our site to avoid this in the future, please have your system administrator contact [email protected] From the 179 patients who were engaged in this study, 28 subjects were excluded due to insufficient data. However, 76% required multiple continence procedures.

(1) Participants with raised LH levels versus participants without raised LH levels. Continence rates were high (diurnal continence in 83% and nocturnal continence in 93%). This includes basic science researchers, urologists, endocrinologists, cardiologists, family practitioners, gynecologists, internists, neurologists, psychiatrists, psychologists, radiologists and other health care clinicians. Protect your erection: 11 tips to help prevent erectile dysfunction. Men with MetS evidenced lower TT circulating levels with an increasing number of MetS parameters, for which hypertriglyceridemia and waist circumference strongly contributed. Study finds higher std rates among users of erectile dysfunction drugs – harvard gazette. 404 T4 (ng/dL), median (P25–P75) 1. 790 Weight (kg), median (P25–P75) 80.

Europe PMC requires Javascript to function effectively. In this study, WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development. Can exercise help with erectile dysfunction (ed)? Some studies have pointed out that normal erectile function is not a prerequisite to remain sexually active [7–9]. Participants with MetS Participants without MetS Without hypogonadism Raised LH levels, (%) Yes 6. Here’s the most recent notice, from the British Journal of Clinical Pharmacology, of a paper that has been cited 23 times, according to Thomson Scientific’s Web of Knowledge:

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Body mass index (BMI) was calculated based on weight in kilograms and height in meters (kg/m2). (8), respectively. This was also true when only the patients with hypogonadism were considered, suggesting that other factors than MetS and obesity, such as age or any of the molecules described above, might have a stronger influence on the HPG axis. The higher the price, the better the quality of the merchandise. On the other hand, as shown in Figure 2, estradiol levels varied in patients with hypogonadism, which was related to dissimilarities in LH levels ( ).

  • This new study provides some insight.
  • Moreover, the sample size was sometimes a limiting factor to test some hypothesis.
  • 072 ng/mL [28].
  • 7%) or in the past (42.
  • The results were so bad that the paper had to be edited again.

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A known history of neurological disease, pelvic trauma, major psychiatric disorder, hepatic failure, end-stage renal disease, or drug abuse was an exclusion criterion. Smoking habits were majorly absent (36. )Possible explanations for this unexpected profile of estradiol may be the age-related adiposity, other estrogen-raising pathways, or even unknown mechanisms. Participants were considered obese if BMI was 30 kg/m2. Conversely, patients without MetS evidenced median TT of 5. Dangers of 'herbal viagra': what every man should know. In spite of such observations, the presence of MetS did seem not to influence TT and FT levels amongst patients with hypogonadism.

However, TT levels were decreased consistently with the increase of the number of parameters of MetS ( ) (Figure 1). However, the science community has also noted that review articles typically are more citable than research articles. The term mixed hypoandrogenism (primary and secondary) was proposed for this phenomenon [9, 31]. Publisher/Sponsor Person or entity that supported the publishing or distribution of a work.

Hypogonadism was present in 23. It is likely that the underlying ED, a common feature of all of our patients, might play a multi-factorial masking role. Your interest in reviewing is shared with journals or conferences when they are partnered with us.

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Erectile dysfunction (ED) is the persistent inability to attain and/or maintain an erection of sufficient rigidity for sexual intercourse. Fertility was achieved in 67% of men and 100% of women. Thus, the number of RCTs published in the IJIR over time has remained constant while their quality has improved. Paper quality checking service is in demand among researchers who wish to make final improvements to their work before submitting it to the target journal. Indeed, among ED patients, obese men present lower T levels compared to those observed in the elder [15]. Place of Publication Where the publisher of the source is.

The lower estradiol levels observed in this peculiar group of patients suggest that they may be influenced by mechanisms that are not yet unveiled. Current or past alcohol consumption was absent in the majority of patients (61. )LH levels were within normal range or decreased in 136 patients, regardless of the presence of MetS.

471 SJR SCImago Journal Rank (SJR indicator) is a measure of scientific influence of scholarly journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from.

The experienced editors of ORES, who have published papers in cited journals, with the participation of foreign partners go through finished articles. From several studies in this area, the importance of understanding the complex interactions between those entities became clear, as well as the underlying modulating factors. Although possible unforeseen confounders might also be influencing this relation, the greatest efforts were made in order to exclude patients with known underlying pathologies or comorbidities that could influence the hormonal results. OCLC’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus issues in their communities. Sexual dysfunction in the military, " What is clear, though:. Thus, taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident [8, 20].

AB - The quality of randomized controlled trials (RCTs) reported in the International Journal of Impotence Research (IJIR) was analyzed.

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However, the relationship between the latter and ED is still controversial [21–23]. Spinal surgery diminishes low back pain, improves sexual function, larkin to review the records and to render his opinion about the nature and extent of the employee=s injury, about his need for ongoing treatment and about his permanent partial disability rating. Hypogonadism and MetS strongly increase the risk of ED at any age and both are risk factors for CV disease [9, 25–27]. Your browser does not support JavaScript and some functionality on this web page will be lost.

Then I decided to save money and chose another company to edit the manuscript. 164 TSH ( U/mL), median (P25–P75) 1. 541 Frequent 41. 46 CiteScore CiteScore is essentially the average citations per document that a title receives over a three-year period. Applying this selection criteria to our database resulted in a series of 29 patients. However, even in this setting, the absence of estradiol effect on LH secretion is still puzzling. ED has been linked to metabolic syndrome (MetS) [4], which is an assembly of cardiovascular (CV) and metabolic risk factors, such as visceral adiposity, insulin resistance/diabetes, high blood pressure, and dyslipidemia.

A Survey of ED Patients' Insights and Treatment Expectations A better understanding of patients' needs and expectations of ED treatment will help physicians choose an optimum treatment method and improve adherence.

Data are expressed as the 25th percentile–the 75th percentile (P25–P75). Cbd for erectile dysfunction: what you need to know. Hence, aging being associated with an increase in adipose tissue accretion, a link between age and hypogonadism was established [32]. 8% reported a current frequent intake (until 37 gr of alcohol per day) and 1. On the other hand, when considering data from patients with an estrogenic HPG axis-attenuation effect but without MetS, possible explanations may imply additional molecules, age-related fat deposits, or other estrogen-raising mechanisms. (6530), when compared to patients without MetS ( ).

Its prevalence has a tendency to increase over time [1], being expected a worldwide increase of 12.

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The whole process from submission to acceptance took less than 3 months. Moreover, multivariate regression analysis demonstrated that within MetS, WC ( ) and hypertriglyceridemia ( ) were independently associated with a decrease in serum T levels. The aim of this study was to determine the long-term sexual outcomes of patients with EEC.

(2) — — — Alcohol intake, (%) Absent 70. The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF- , and other adipokines, were proposed candidates [15, 27]. Interestingly, among those with higher LH levels, estradiol values were also increased. All patients underwent a standardized physical examination protocol.

Assisted reproductive technology was needed in one man.

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Hypo- and hyperinsulinemia were considered at insulin levels inferior to 2. 3% reported being active smokers. Aiming to establish further relations amongst the conditions described above, several authors observed that the MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion [27]. 001 Height (cm), median (P25–P75) 179. Several studies support LOH, unveiling that T levels decrease along aging [14, 16, 18, 19]. Normally, journals with higher impact factors are often deemed to have more influence than those with lower ones. All product names, trademarks and registered trademarks are property of their respective owners. They were placed on your computer when you launched this website.