In addition, NO suppresses vascular inflammation by reducing the expression of leukocyte adhesion molecules and inflammatory cytokines [17-20]. Zhou’s veggie capsules prove to be not only vegetarian-friendly but also healthy with the inclusion of their beetroot extract. Nitric oxide is a vasodilator — it increases blood flow by relaxing the muscles along the inside wall of your blood vessels, allowing the vessels to widen. The study included 50 men with confirmed organic ED who were randomized after a 2‐week placebo run‐in period to receive l‐arginine or placebo. The plasma and urinary NO x levels were no different between the groups at baseline (at the end of the placebo run‐in period). It’s now well known that ED is connected to cardiovascular disease, and reduced nitric oxide may help explain the link.

  • For more than three decades I have raced more than 300 endurance events, including more than 150 triathlons of Olympic distance or longer, 103 marathons and numerous other events including ultramarathons and rough water swims from Alcatraz to the mainland.
  • In a sense, we do not change as we become adults.
  • It acts by activating nitric oxide secretion and enhancing testosterone synthesis.
  • There are some purported nitric oxide supplements, however, which end up being disappointments.
  • Pycnogenol has recently been isolated as an anti-hypertension aid.

For more information, including dosage and safety issues, see the full L-arginine article. Erectile dysfunction, testosterone can be replaced through injections, skin patches, gels, or tablets placed between the cheek and gums. ” Some people think they are getting older and that they do not have energy like they used to. There is pre-clinical evidence, and some clinical experience indicating that yohimbine can enhance sexual function [83-85]. But since that time, the product formula was substantially changed.

Recommended doses of L-arginine or L-citrulline are 5-6 g per day, taken in divided doses between meals. 8 milligrams of nitrate per kilogram of body weight. Increasing nitric oxide is a powerful way to get more out of your workouts and recover faster, and to enhance your sex life. Infusions of L-arginine also appear to reduce blood pressure in people with hypertension.

It means you have a slightly raised blood pressure reading of 120/80 to 139/89. Indirect vasodilation by inhibiting vasoconstrictor influences (e. )A double-blind, placebo-controlled study enrolled 40 men with difficulty achieving or maintaining an erection who also had low measured levels of dehydroepiandrosterone (DHEA). What erectile dysfunction might be trying to tell you. In one 10-year study, men who had sex two or more times per week experienced half as many heart attacks as did those who had sex less than once per month.

Finally, the vasodilating properties of nitric oxide might be a useful way to reduce risk factors for heart disease, such as high blood pressure.


Effect of oral zinc therapy on gonadal function in hemodialysis patients. Nitric oxide first rocketed to popularity in the sports nutrition world because of evidence that it improves endurance performance. For example, a 2020 review of top-selling supplements for men's sexual health, published in The Journal of Sexual Medicine, found little or no evidence to support claims they could improve aspects of sexual performance. Click here for directions and contact information. In a pilot study, patients with PAD and intermittent claudication (n = 80) were randomly assigned to oral doses of 0, 3, 6 or 9 g of L-arginine daily in three divided doses for 12 weeks [85]. Phosphodiesterases, or PDE, degrade the cGMP, which causes the blood vessels to constrict. Plasma and urine nitrite and nitrate (designated NO x ), both stable metabolites of nitric oxide, were determined at the end of the placebo run‐in period, and after 3 and 6 weeks. The recommended dosage for cocoa extract is 500-1,000mg (37).

Cicero AF, Piacente S, Plaza A, et al. Being sedentary leads to less Nitric oxide production because your body is not stimulating its production; production is stimulated during exercise. The four ingredients are potent nitric oxide boosters and antioxidants which optimize your health. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. L-arginine undergoes extensive first-pass metabolism by arginase in the small intestine and liver. 6% of the patients in the KRG group reported improved erections while the placebo group was not significantly different from baseline. If you suffer from prostate enlargement, had prostate surgery or don’t have prostate at all, you don’t have to be afraid of using the male-enhancing pills which fight erectile dysfunction.

In the vasculature, NO released by the endothelium induces vasodilation and increases blood flow. Garlic and erectile dysfunction, it’s also important to stay hydrated. It is very important to note that nitric oxide supplements are not a treatment for type 2 diabetes, nor can they prevent the disease on their own. 21 It has been shown to be a good antioxidant22 and has positive effect on cardiovascular functions.

35 If this were true, men with erectile dysfunction would be advised to avoid use of these herbs.

General Information

Nitric oxide is actually a gas, but it’s produced on the cellular level inside your body to regulate how bloodflow works in your muscles (as well as the rest of your body). The study used beetroot juice which is a good source of nitrate, but it only tested 9 healthy, physically active males – which is quite a small number. Consider just a few factors about the link between the lifestyle changes we recommend and your heart health: A 2020 South Korean study found that taking the herb for just a few weeks improved guys’ performance in the bedroom, including helping them last longer before finishing. If you eat cured meats, get some veggies alongside them.

You should also consider adding one or two cups daily of fresh or dehydrated beet juice, which is sold in health food stores. Robot check, cortisol is catabolic, which means it promotes muscle breakdown. Can nitric oxide supplements help with erectile dysfunction? Unicorn juice? There are many men who don’t trust any medications.

Research conducted at the University of Leicester reveals how NO can change the “computational ability” of the brain, which points toward NO’s ability to help neurodegenerative diseases, such as Alzheimer’s disease. Below, you’ll find a guide to the benefits, suggested dosages, and side effects of the best nitric oxide supplements. While research is still in its early stages, a scientific article published in 2020 concludes that “dietary nitrate supplementation appears to represent a promising new approach for enhancing aspects of the physiological response to exercise, such as muscle efficiency and oxygenation, which might augment performance. Studies shows a small to moderate improvement in sexuality in both genders affecting approximately 2/3rds of participants.

What is ED?

The level of urinary NOx in this subgroup had doubled by the end of the study, suggesting that patients with low levels of NOS activity may be particularly benefited by L-arginine supplementation [71]. Ways to naturally treat erectile dysfunction (ed), but you may be dealing with erectile dysfunction when the following symptoms are persistent:. Instead, they mildly restore erectile function in men, increase libido and endurance, improve sperm characteristics, enhance the overall sexual performance, and give a boost to intimate self-esteem. Though they do provide L-arginine and L-citrulline in amounts that have been proven to be effective, they also provide some additional amino acids for increased performance. During the development of Eisenmenger Syndrome, a reversal of blood flow occurs.

Oral meds for ED are highly effective, and several are available, including Viagra (sildenafil), Cialis (tadalafil) and Levitra (vardenafil).

Human Effect Matrix

A double-blind study. One study from 1999 found that L-arginine was no more effective as a first-line treatment for impotence than a placebo. The main function of nitric oxide is vasodilation of the blood vessels which can help to prevent cardiovascular disease, improve cognition, and improve recovery. Nitric oxide is well known these days because it is the target of drugs like sildenafil (Viagra), which treat erectile dysfunction(ED). According to the laboratory investigations, a few hundreds of products contain hazardous active substances.

  • These causes typically require serious medical aid.
  • What does nitric oxide do for the body?
  • It’s important to note, though, that nitric oxide is far from the only factor that plays into any of these outcomes.
  • Inadequate amounts of the sex hormones, referred to as andropause in men and menopause in women can lead to decreased libido, fatigue, weight gain, loss of muscle mass, loss of strength, poor skin tone, increased cardiovascular issues, decreased bone density, disturbed sleep, and depression.
  • Grilling or roasting is acceptable as long as the garlic is sliced or crushed.

Ingredients in AFFIRM

This has led researchers to focus on nitric oxideas a potential target for medical therapies. This can be a reason why a man struggles with erectile dysfunction. When considering nitric oxide supplements for ED, L-citrulline is another option. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. 7 surprising reasons for erectile dysfunction, many men with diabetes also experience a decreased sex drive, often as a result of hormone imbalances or depression. It does many things, including acting as a vasodilator. For more about receiving EECP therapy at the Whitaker Wellness Institute, click here, or call (866) 944-8253. What is the best vitamin to help me with erectile dysfunction? Until recently, yohimbine hydrochloride was the most widely used oral medication for ED, but the outcome was disappointing, even when it was used in high doses [18]. Since nitric oxide stimulates cGMP to keep the blood vessels open, then it makes sense that nitric oxide boosters may also address some erectile dysfunctions.

Some can cause side effects or interact with other medications. Please note the date of last review or update on all articles. And the well-reputed ED pills of natural origin are not an exception.

Vitamin D

For a supplement that provides so much, it is impressive that they can use top-tier ingredients while keeping a realistic price point. But in every other way, its precursor L-citrulline is the better choice for your money. Ibuprofen may increase risk of fertility issues in men, study suggests, the catheter is generally left in place for at least 24 to 48 hours, until swelling decreases and you're able to urinate on your own. Nitric oxide can help with a wide variety of health conditions by altering bloodflow.

But beets contain a high amount of sugar, so they’re classified as a “suspect” food on the Bulletproof Diet.

The minimum recommended dosage of raw garlic is a single garlic clove, two or three times a day with meals. The first thing we looked at was the ingredient list. It appears that low levels of L-citrulline and L-arginine my increase erectile dysfunction risk by reducing the concentration of nitric oxide in the body. Take a daily multivitamin that contains high doses of antioxidants.

But unlike prescription medications for erectile dysfunction, such as sildenafil (Viagra), vardenafil (Levitra, Staxyn), tadalafil (Cialis, Adcirca) and avanafil (Stendra), erectile dysfunction herbs and supplements haven't been well-studied or tested. Gas what: no is not the only answer to sexual function. The information contained within this article is solely for informational purposes only. Since the demand for the alternative ED remedies exists, the manufacturers invented special cream with the male enhancement properties. There are also useful tips that will easily help you enhance sexual health if you adhere to them regularly. A small amount of research suggests that taking citrulline will lead to higher and more consistent arginine levels than taking arginine. They'll tempt you with their marketing promises, but beware the dangers hidden within. Erectile dysfunction and diabetes: what's the link?, the benefits of continued drug therapy with these drugs should always be weighed against the likelihood of causing ED and impacting on the patient's QOL. 1 nitric oxide capsule 3 times daily or as directed. NO synthesized by the endothelial isoform of NO synthase (NOS) in the endothelium, and by the neuronal isoform (nNOS) in the nitrergic nerves.


Interestingly with Chen et al,10 it was noted that those reported improvement had low urinary nitrite/nitrate, the excreted metabolic products of NO, suggesting that those with low NO levels are more likely to improve with l-arginine supplementation. Because you can’t take nitric oxide directly as a supplement, it is pretty much impossible to get any side effects from it. Marijuana and sexual dysfunction: what you should know, , anticipation, plateau, orgasm, and decline). If the supplements you’re taking have beets in them, they may turn your stool red. Guanidinoacetate methyltransferase deficiency: In response to sexual stimulation, the nitrergic nerves are activated, releasing NO to induce vasodilation. Being in excellent health means no smoking, drinking limited amounts of alcohol, eating healthy balanced meals with appropriate amounts of healthy fat, exercising often, and drinking plenty of water. L-carnitine – A study published in the International Journal of Vitamin & Nutrition Research (2020) found that 3g of L-Carnitine was able to significantly increase nitric oxide levels (42). This explains why nitroglycerin is such an effective therapy for angina.

By increasing blood flow to your muscles, the oxygenation of your muscular tissue increases when your nitric oxide levels are higher.
You can get folic acid from oranges, leafy green vegetables, bread and grains, cereals, pasta, rice, and beans.

If You Have Diabetes

Testosterone and Sex Learn about the risk and benefits of testosterone therapy. L-arginine can worsen allergies or asthma. The vitamin helps increase blood flow and reduce inflammation—one of the underlying causes of both high cholesterol and erectile dysfunction. Exercise not only gives your heart a workout and burns off yesterday’s pasta; it also pumps your nitric oxide and reduces inflammation. However, in a subsequent study, patients (n=150) patients with acute myocardial infarction were randomized to placebo or L-arginine supplementation for a longer term of therapy (6 months) following acute myocardial infarction. But again, it really is best to talk with a healthcare provider at the first sign of ED. Chronic low levels of nitric oxide can lead to high blood pressure, kidney disease, and heart disease.

No serious adverse effects were observed during L-arginine supplementation. It really cures the impairment of erectile function instead of just giving an erection that will last for a couple of hours. Both the physical and sexual performance enhancing effects of nitric oxide can be attributed to its ability to trigger smooth muscle relaxation and therefore vasodilation. The inclusion of Bioperine is typically done to boost absorption of certain biologically active compounds, which further underscores N. Int J Impot Res. ” It activates relaxation of the smooth muscle in the penis. A quick Amazon search reveals pages of results.

How We Ranked

This increases blood flow, which is needed to initiate and maintain an erection. To restore access and understand how to better interact with our site to avoid this in the future, please have your system administrator contact [email protected] Zava, 20, 24 followed by injections of drugs into the penis, as well as penile implants. Nitrate is a precursor to nitric oxide, and eating foods high in nitrates can increase nitric oxide levels throughout the body[25][26].

Today, supplements that raise nitric oxide levels are very popular. Can anxiety lead to erectile dysfunction? Effect of lifestyle changes on erectile dysfunction in obese men. Am J Psychiatry. Can too much nitric oxide be harmful? This has led some people to hypothesize that the relationship works in reverse, too–i. Arginine and weight training: The proven otc ED supplements not only have the long term therapeutic effect by substantially improving all the aspects of erection quality. If you have type 2 diabetes, chances are your body doesn’t produce as much nitric oxide as it needs to.


The researchers were able to show that the citrulline supplement (as well as a nitrate supplement which directly boost nitric oxide levels) was able to reduce blood pressure and improve the oxygenation of peripheral tissue in the body. Scientific studies have proven L-Citrulline supplementation increases blood levels of L-Arginine more effectively than supplementation of L-Arginine alone. 5,41 This profile favors the “as in when required” use of the combination. The mentioned ED pills have a very high efficacy rate since they prove to comply with the customers’ expectations in more than 80% of cases.

” These remedies may interact with your medications or exacerbate pre-existing conditions.

Since the cells use arginine to create nitric oxide, you can also consider increasing your arginine intake through high-protein foods rich in arginine, including grass-fed beef; wild-caught fish, cage-free eggs, dairy products like cultured yogurt, kefir, raw cheeses, seeds like pumpkin and sunflower seeds, seaweed, and spirulina. However, more research is necessary to really understand its efficacy. Intracavernosal injection for the diagnosis, evaluation, and treatment of erectile dysfunction: a review. You can also boost your nitric oxide levels naturally by eating foods rich in nitrates. Use of this erectile dysfunction medication with L-arginine might cause your blood pressure to become too low. It has been shown that there is reduced NO bioactivity in erectile dysfunctions (ED) 3 as l-arginine is a natural precursor of NO and its good availability is understood to have positive effect on NO production. We have shown that the enzyme activity is impaired with a number of disorders associated with cardiovascular disease including hypercholesterolemia, diabetes mellitus, and hyperhomocysteinemia [57-59]. People with cirrhosis, or liver scarring, should take nitric oxide cautiously as it could worsen liver function.

In a 6-month, double-blind trial of 120 men, average age 66, carnitine (propionyl-l-carnitine 2 g/day plus acetyl-l-carnitine 2 g/day) and testosterone (testosterone undecanoate 160 mg/day) were separately compared to placebo.

Make sure you stop before you burn; the right amount of sunlight is amazing for you in all kinds of ways, but if you push it to the point where you get a sunburn, you increase your risk of skin cancer by a lot. Studies using beet root powder, a very good source of nitric oxide, found substantial increases in endurance thanks to increased levels of nitric oxide. “Ginseng is a promising herbal therapy for ED because it helps promote relaxation of smooth muscle in the penis, increase dopamine levels in the brain, and increase pressure in the cavernosal nerves of the penis which helps nitric oxide synthesis,” Walker explains.

In general, nitric oxide is safe for most people when taken in the proper doses.

Erectile Dysfunction Overview

Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Drago F, Busa' L. Be careful though, raw garlic has been shown to be toxic in high dosages. Although the Food and Drug Administration has banned many of these products, some potentially dangerous erectile dysfunction remedies remain on the market.

If all of that wasn’t enough to convince you that this supplement is worth your time, you should consider the price point involved.

When should I try vitamins instead of ED medication?

In fact, Viagra and Cialis, the two most popular erectile dysfunction medications, both work by stimulating nitric oxide pathways in the penis, relaxing blood vessel muscles so more blood can flow through. Sexual activity burns 100 to 200 calories, or the equivalent of walking one to two miles. Nitric oxide can be most easily and safely be increased via dietary sources. The number one reason why people take nitric oxide enhancing supplements is to improve their workout quality. But despite the calculations of enzymologists, and in apparent contradiction of Michaelis-Menton kinetics, our observations were confirmed by a number of other groups [40-45]. Erectile dysfunction and your health: 5 things , thiazides are the most common cause of erectile dysfunction among the high blood pressure medicines. Cialis, or Tadalafil, is one of Viagra’s main competitors. Soy or soy isoflavones , 21 as well as the herb licorice , 10 may reduce testosterone levels in men. It’s the presence of this final ingredient that pushes NO Pro to the top of the stack.

A placebo-controlled, double-blind trial of Ginkgo bilboa for antidepressant-induced sexual dysfunction. These drugs are the strong artificial ones which substantially increase nitric oxide levels. Erectile dysfunction is a medical condition which implies the occurrence of a very troubled and weak erection or a complete absence of an erection for at least several months. Conaglen HM, Suttie JM, Conaglen JV. Often found in fat burners and pre workouts, when you take one of these, you’re not ingesting actual nitric oxide, but rather a nitric oxide precursor that is thought to encourage more NO production in the body.

The PDE-5 inhibitors increase penile blood flow by inhibiting the degradation of cyclic guanosine monophosphate (cGMP) by its phosphodiesterase (Figure 1).
  • You can also find a list of foods that increase nitric oxide on this site.
  • 5 g (Bloomer et al.)

I’m Staying on the Sidewalk, Daddy: Mistakes and Triumphs in Parenting

Can nitric oxide supplements cause stomach issues? Purchase a subscription to gain access to this and all other articles in this journal. Suggested dosage for L-citrulline: Niacin is naturally found in foods like turkey, avocado, and peanuts.

Inflammation: The Long, Slow Burn, and How It Harms Your Body

Derived from the bark of a West African evergreen tree, yohimbe was the go-to ‘script for a wonky willy prior to the advent of wonder drugs like Viagra, Walker says. In addition to the Ohio office, Dr. Type 2 diabetes may be linked to erectile dysfunction. Those who did not take the same supplements found blood pressure readings to be significantly higher than other test subjects (33).

Furthermore, diabetes mellitus favors the production of advanced glycosylation endproducts (AGEs) which can also disrupt eNOS activation, as with formation of N-acetylglucosamine (OGIcNAc) adducts with serine phosphorylation sites on eNOS. Moreover, supplements geared towards overall workout performance or male sexual wellness include nitric oxide boosters as well. What they discovered is still the subject of literally thousands of pieces of research annually. Produced by the endothelial cells lining the arteries, it penetrates the underlying smooth muscles and acts as a potent vasodilator that relaxes the arteries. But the use of cream can cause much more troubles than you may imagine. If you have high blood pressure, you should always seek advice from your doctor before using any supplement or medication. If you aspire to overcome erectile dysfunction by means of natural over the counter ED pills, you should first of all look for the nitric oxide supplements for ED. The results indicate that while using Korean red ginseng men experienced significantly better sexual function than while they were taking placebo.

Alcohol is incompatible with these medications. These are some delicious recipes to try that are loaded with vegetables rich in dietary nitrates that can help boost NO levels in the body. What causes erectile dysfunction and what can you do about it? Gomez F, Davila H, Costa A et al:. You should never rely upon this article for specific medical advice.

Hormone Therapy

Manufacturers can also make L-citrulline in a laboratory and package it as a pill or powder. The recommended dosage for L-citrulline is 3 x 1,000mg per day (36). Possible symptoms of a NO deficiency include hypotension, insomnia, anxiety, loss of libido and erectile dysfunction. ” L-arginine supplements: The recommended dosage for fish oil is 250mg (40). After treatment, most were able to reduce or discontinue their drugs, avoid invasive procedures, and return to an active, productive lifestyle. Nitric oxide also speeds up recovery and prevents muscle soreness.